Heatstroke pathophysiology: the energy depletion model.

Heating Causes a Rise in the Concentration of Intracellular Sodium in Human Cells in Vitro

A rise in intracellular sodium ion concentration ([Na+]i) was predicted by Hubbard in his "energy depletion mechanism" of heatstroke [ l ] but such rises have not been clearly shown. In this study, we have found rises in [Na+]i at elevated temperatures in isolated human squamous epithelial cells, by measuring changes in the fluorescence of a Na+-sensitive fluorophore which had been introduced i...

Application of a model of exertional heatstroke pathophysiology to cocaine intoxication.

Heatstroke: thermoregulation, pathophysiology, and predisposing factors.

Heatstroke is a common veterinary emergency that, depending on the severity of injury, can progress to a life-threatening condition. Heatstroke can be classic (nonexertional) or exertional. Classic heatstroke develops when the body is exposed to high external temperatures, whereas exertional heatstroke is caused by strenuous exercise. Thermoregulation is the intrinsic ability of the body to mai...

Hemmelgarn , DVM

Heatstroke is a complex disease process that, in its most severe form, can result in multiorgan dysfunction and death. Heatstroke stems from the failure of the body’s thermoregulatory mechanisms, resulting in cellular damage and death. The organ systems most commonly affected in this disease process include the gastrointestinal tract and the coagulation, renal, cardiac, pulmonary, and central n...

Microvascular injury, thrombosis, inflammation, and apoptosis in the pathogenesis of heatstroke: a study in baboon model.

OBJECTIVE Severe heatstroke is a leading cause of morbidity and mortality during heat waves. The pathogenesis of tissue injury, organ failure, and death in heatstroke is not well understood. METHODS AND RESULT We investigated the pathways of heatstroke-induced tissue injury and cell death in anesthetized baboons (Papio hamadyras) subjected to environmental heat stress until core temperature a...